منابع مشابه
Soaking up stress
Text by Rabiya S. Tuma [email protected] Soaking up stress O n page 115, Ku and Omary add one more function to keratin’s expanding repertoire. In addition to acting as a structural protein in liver cells, keratin 8 (K8) apparently absorbs excess phosphorylation during stress and thus reduces the likelihood of apoptosis. Humans who carry a G61C polymorphism in K8 are predisposed to liver disease w...
متن کاملInducing RNAi in Drosophila cells by soaking with dsRNA.
RNA interference (RNAi) triggered by synthetic long double-stranded RNAs (dsRNAs) has been applied in many Drosophila cell lines to study the functions of individual genes or for genome-wide scans. One contributor to the popularity of this approach is that many fly cell lines spontaneously take up dsRNAs from media, obviating the need for assisted uptake methods such as transfection. In this pr...
متن کاملSoaking RNAi in Bombyx mori BmN4-SID1 Cells Arrests Cell Cycle Progression
RNA interference (RNAi) is an evolutionarily conserved mechanism for sequence-specific gene silencing. Previously, the BmN4-SID1 cell expressing Caenorhabditis ele gans SID-1 was established, in which soaking RNAi could induce effective gene silencing. To establish its utility, 6 cell cycle progression related cDNAs, CDK1, MYC, MYB, RNRS, CDT1, and GEMININ, were isolated from the silkworm, Bomb...
متن کاملUP-TORR: online tool for accurate and Up-to-Date annotation of RNAi Reagents.
RNA interference (RNAi) is a widely adopted tool for loss-of-function studies but RNAi results only have biological relevance if the reagents are appropriately mapped to genes. Several groups have designed and generated RNAi reagent libraries for studies in cells or in vivo for Drosophila and other species. At first glance, matching RNAi reagents to genes appears to be a simple problem, as each...
متن کاملProblem solving by soaking the concept network
Because of the complexity and fuzziness of the real world, it’s hard to build a dense knowledge system and reason in it with traditional methods. But man can deal with such tasks freely. Inspired by cognition and linguistics, a solution is advanced for reasoning dense knowledge in this paper. Objects and concepts are organized in the form of concept graph. Soaking the nodes in the graph until t...
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ژورنال
عنوان ژورنال: Molecular Cell
سال: 2003
ISSN: 1097-2765
DOI: 10.1016/s1097-2765(03)00352-6